Championing chrononutrition with protein, the morning elixir for muscle growth
Waseda University
Proteins constitute an essential dietary component that help in the growth and repair of the body. Composed of long chains of amino acids, proteins promote the growth of skeletal muscles, the group of muscles that help us move.
The reason behind this is the body's internal biological clock, called the 'circadian rhythm.' This rhythm is followed by all cells and controls life functions like metabolism and growth. Interestingly, protein digestion and absorption have been found to fluctuate across day and night according to this clock.
Moreover, earlier studies have reported that intake of protein at
breakfast and lunch promotes skeletal muscle growth in adults. However, details
on the effect of the time of protein intake on muscle growth and function have
remained elusive till date.
Fortunately, researchers from Waseda University, led by Professor Shigenobu Shibata, recently endeavored to understand the effect of the distribution of protein intake through the day on muscles.
They fed laboratory mice two meals per day containing either high (11.5% by proportion) or low (8.5% by proportion) protein concentrations. The researchers noted that protein intake at breakfast induced an increase in muscle growth, determined by assessing induced hypertrophy of the plantaris muscle in the leg, when compared with the effects of protein intake at dinner.
Specifically, the ratio of muscle hypertrophy
determined against the growth of the control muscle was 17% higher in mice fed
8.5% protein at breakfast, than that in mice fed 11.5% protein at dinner,
despite the former group consuming a low proportion of protein overall. They
also found that intake of a type of protein called the BCCA, short for
branched-chain amino acids, early in the day increased the size of skeletal
muscles specifically.
To
confirm the association of these effects with the workings of the circadian
rhythm, the researchers next engineered whole-body mutant Clock?19 or
muscle-specific Bmal1 knockout mice lacking the genes that
control the biological clock. They repeated diet distribution experiments on
these mice but did not observe similar muscle change, which confirmed the
involvement of the circadian rhythm in muscle growth in the context of protein
intake.
Excited
about the findings of their study published in a recent issue of the Cell
Reports, Prof. Shibata emphasizes, "Protein-rich diet at an early
phase of the daily active period, that is at breakfast, is important to
maintain skeletal muscle health and enhance muscle volume and grip
strength."
To check if their findings were applicable to humans, the team recruited women in their study and tested if their muscle function, determined by measuring skeletal muscle index (SMI) and grip strength, varied with the timing of the protein-rich diet consumed.
Sixty women aged 65 years and above who took
protein at breakfast rather than at dinner showed better muscle functions,
suggesting the possibility of the findings to be true across species.
Additionally, the researchers also found a strong association between SMI and
the proportion of protein intake at breakfast relative to total protein intake
through the day.
Prof. Shibata is hopeful that the findings of their study will lead to a widespread modification in the current diet regime of most people across the Western and Asian countries, who traditionally consume low amounts of protein at breakfast.
He therefore stresses, "For humans, in general, the protein intake at
breakfast averages about 15 grams, which is less than what we consume at
dinner, which is roughly 28 grams. Our findings strongly support changing this
norm and consuming more protein at breakfast or morning snacking time."
It
seems, a simple change in our dietary regime can be our key to ensuring healthy
muscles.
