University of California - San Diego
Researchers at University of California San Diego School of
Medicine report that elderly women who sit for more than 10 hours a day with
low physical activity have cells that are biologically older by eight years
compared to women who are less sedentary.
The study, publishing online January 18 in the American
Journal of Epidemiology, found elderly women with less than 40 minutes of
moderate-to-vigorous physical activity per day and who remain sedentary for
more than 10 hours per day have shorter telomeres -- tiny caps found on the
ends of DNA strands, like the plastic tips of shoelaces, that protect
chromosomes from deterioration and progressively shorten with age.
As a cell ages, its telomeres naturally shorten and fray, but
health and lifestyle factors, such as obesity and smoking, may accelerate that
process. Shortened telomeres are associated with cardiovascular disease,
diabetes and major cancers.
"Our study found cells age faster with a sedentary lifestyle. Chronological age doesn't always match biological age," said Aladdin Shadyab, PhD, lead author of the study with the Department of Family Medicine and Public Health at UC San Diego School of Medicine.
Shadyab and his research team believe they are the first to
objectively measure how the combination of sedentary time and exercise can
impact the aging biomarker.
Nearly 1,500 women, ages 64 to 95, participated in the study.
The women are part of the larger Women's Health Initiative
(WHI), a national, longitudinal study investigating the determinants of chronic
diseases in postmenopausal women.
The participants completed questionnaires and wore an
accelerometer on their right hip for seven consecutive days during waking and
sleeping hours to track their movements.
"We found that women who sat longer did not have shorter
telomere length if they exercised for at least 30 minutes a day, the national
recommended guideline," said Shadyab.
"Discussions about the benefits of exercise should start
when we are young, and physical activity should continue to be part of our
daily lives as we get older, even at 80 years old."
Shadyab said future studies will examine how exercise relates to
telomere length in younger populations and in men.
