Discovery
builds on previous evidence of cancer-prevention
benefits
Ohio State University
Daily tomato consumption appeared to cut the development of skin
cancer tumors by half in a mouse study at The Ohio State University.
Daily tomato consumption appeared to cut the development of skin
cancer tumors by half in a mouse study at The Ohio State University.
The new study of how nutritional interventions can alter the
risk for skin cancers appeared online in the journal Scientific Reports.
It found that male mice fed a diet of 10 percent tomato powder
daily for 35 weeks, then exposed to ultraviolet light, experienced, on average,
a 50 percent decrease in skin cancer tumors compared to mice that ate no
dehydrated tomato.
The theory behind the relationship between tomatoes and cancer is that dietary carotenoids, the pigmenting compounds that give tomatoes their color, may protect skin against UV light damage, said Jessica Cooperstone, co-author of the study and a research scientist in the Department of Food Science and Technology in the College of Food, Agricultural, and Environmental Sciences at Ohio State.
There were no significant differences in tumor number for the
female mice in the study. Previous research has shown that male mice develop
tumors earlier after UV exposure and that their tumors are more numerous,
larger and more aggressive.
"This study showed us that we do need to consider sex when
exploring different preventive strategies," said the study's senior
author, Tatiana Oberyszyn, a professor of pathology and member of Ohio State's
Comprehensive Cancer Center.
"What works in men may not always work equally well in
women and vice versa."
Previous human clinical trials suggest that eating tomato paste
over time can dampen sunburns, perhaps thanks to carotenoids from the plants
that are deposited in the skin of humans after eating, and may be able to
protect against UV light damage, Cooperstone said.
"Lycopene, the primary carotenoid in tomatoes, has been
shown to be the most effective antioxidant of these pigments," she said.
"However, when comparing lycopene administered from a whole
food (tomato) or a synthesized supplement, tomatoes appear more effective in
preventing redness after UV exposure, suggesting other compounds in tomatoes
may also be at play."
In the new study, the Ohio State researchers found that only
male mice fed dehydrated red tomatoes had reductions in tumor growth.
Those fed
diets with tangerine tomatoes, which have been shown to be higher in
bioavailable lycopene in previous research, had fewer tumors than the control
group, but the difference was not statistically significant.
Cooperstone is currently researching tomato compounds other than
lycopene that may impart health benefits.
Non-melanoma skin cancers are the most common of all cancers,
with more new cases -- 5.4 million in 2012 -- each year than breast, prostate,
lung and colon cancers combined, according to the American Cancer Society.
Despite a low mortality rate, these cancers are costly,
disfiguring, and their rates are increasing, according to the U.S. Department
of Health and Human Services.
"Alternative methods for systemic protection, possibly
through nutritional interventions to modulate risk for skin-related diseases,
could provide a significant benefit," Cooperstone said.
"Foods are not drugs, but they can possibly, over the
lifetime of consumption, alter the development of certain diseases," she
said.
