Low
levels of alcohol good for the brain
University of Rochester Medical Center
While a couple of glasses of wine can help clear the mind after
a busy day, new research shows that it may actually help clean the mind as
well. The new study, which appears in the journal Scientific Reports, shows that low levels of alcohol consumption tamp down inflammation and helps the brain clear away toxins, including those associated with Alzheimer's disease.
"Prolonged intake of excessive amounts of ethanol is known
to have adverse effects on the central nervous system," said Maiken
Nedergaard, M.D., D.M.Sc., co-director of the Center for Translational
Neuromedicine at the University of Rochester Medical Center (URMC) and lead
author of the study.
"However, in this study we have shown for the first time that low doses of alcohol are potentially beneficial to brain health, namely it improves the brain's ability to remove waste."
"However, in this study we have shown for the first time that low doses of alcohol are potentially beneficial to brain health, namely it improves the brain's ability to remove waste."
The finding adds to a growing body of research that point to the
health benefits of low doses of alcohol. While excessive consumption of alcohol
is a well-documented health hazard, many studies have linked lower levels of
drinking with a reduced risk of cardiovascular diseases as well as a number of
cancers.
Nedergaard's research focuses on the glymphatic system, the brain's unique cleaning process that was first described by Nedergaard and her colleagues in 2012.
They showed how cerebral spinal fluid (CSF) is pumped into brain tissue and flushes away waste, including the proteins beta amyloid and tau that are associated with Alzheimer's disease and other forms of dementia.
Subsequent research has shown that the glymphatic system is more active while we sleep, can be damaged by stroke and trauma, and improves with exercise.
The new study, which was conducted in mice, looked at the impact
of both acute and chronic alcohol exposure.
When they studied the brains of animals exposed to high levels of alcohol over a long period of time, the researchers observed high levels of a molecular marker for inflammation, particularly in cells called astrocytes which are key regulators of the glymphatic system.
They also noted impairment of the animal's cognitive abilities and motor skills.
When they studied the brains of animals exposed to high levels of alcohol over a long period of time, the researchers observed high levels of a molecular marker for inflammation, particularly in cells called astrocytes which are key regulators of the glymphatic system.
They also noted impairment of the animal's cognitive abilities and motor skills.
Animals that were exposed to low levels of alcohol consumption,
analogous to approximately 2 ½ drinks per day, actually showed less
inflammation in the brain and their glymphatic system was more efficient in
moving CSF through the brain and removing waste, compared to control mice who
were not exposed to alcohol.
The low dose animals' performance in the cognitive and motor tests was identical to the controls.
The low dose animals' performance in the cognitive and motor tests was identical to the controls.
"The data on the effects of alcohol on the glymphatic
system seemingly matches the J-shaped model relating to the dose effects of
alcohol on general health and mortality, whereby low doses of alcohol are
beneficial, while excessive consumption is detrimental to overall health"
said Nedergaard.
"Studies have shown that low-to-moderate alcohol intake is associated with a lesser risk of dementia, while heavy drinking for many years confers an increased risk of cognitive decline. This study may help explain why this occurs. Specifically, low doses of alcohol appear to improve overall brain health."
"Studies have shown that low-to-moderate alcohol intake is associated with a lesser risk of dementia, while heavy drinking for many years confers an increased risk of cognitive decline. This study may help explain why this occurs. Specifically, low doses of alcohol appear to improve overall brain health."
