Could
this plaque identifying toothpaste prevent a heart attack or stroke?
Florida Atlantic University
For decades, researchers have suggested a link between oral
health and inflammatory diseases affecting the entire body -- in particular,
heart attacks and strokes. Inflammation is intimately involved in the pathogenesis of atherosclerosis and is accurately measured by high sensitivity C-reactive protein (hs-CRP), a sensitive marker for future risks of heart attacks and strokes.
Researchers from Florida Atlantic University's Schmidt College
of Medicine, Marshfield Clinic Research Institute, and the University of
Wisconsin School of Medicine and Public Health, collaborated on a randomized
trial titled, "Correlation between Oral Health and Systemic Inflammation"
(COHESION), to further explore whether Plaque HD®, a plaque identifying
toothpaste, reduces hs-CRP.
Results of the randomized pilot trial, published online ahead of
print in the American Journal of Medicine, showed that Plaque HD®
produced a statistically significant reduction in hs-CRP among those with
elevations at baseline.
Plaque HD® is the first toothpaste that identifies plaque so that it can be removed with directed brushing. In addition, the product's proprietary formulation contains unique combinations and concentrations of cleaning agents that weaken the core of the plaque structure to help the subject visualize and more effectively remove the plaque.
Plaque HD® is the first toothpaste that identifies plaque so that it can be removed with directed brushing. In addition, the product's proprietary formulation contains unique combinations and concentrations of cleaning agents that weaken the core of the plaque structure to help the subject visualize and more effectively remove the plaque.
In this trial, all randomized subjects were given the same
brushing protocol and received a 30-day supply of toothpaste containing either
Plaque HD® or an identical non-plaque identifying placebo toothpaste. To assess
hs-CRP, levels were measured by Quest Diagnostics using an enzyme linked
immunosorbent assay.
"The current findings are similar to those from our
previous pilot trial," said Charles H. Hennekens, M.D., Dr.P.H., senior
author, first Sir Richard Doll Professor, and senior academic advisor in FAU's
Schmidt College of Medicine.
"Whether this plaque-identifying toothpaste decreases heart attacks or strokes requires a large-scale randomized trial of sufficient size and duration. These results provide a stronger rationale to conduct such trials. If positive, the results of these trials would have significant potential clinical and public health implications."
"Whether this plaque-identifying toothpaste decreases heart attacks or strokes requires a large-scale randomized trial of sufficient size and duration. These results provide a stronger rationale to conduct such trials. If positive, the results of these trials would have significant potential clinical and public health implications."
Based on these findings, Hennekens and colleagues at FAU and the
University of Wisconsin School of Medicine and Public Health are drafting an
investigator-initiated research grant proposal to the National Institutes of
Health (NIH).
Their proposed randomized trial will test whether Plaque HD® reduces progression of atherosclerosis in the coronary and carotid arteries, for which systemic inflammation is an important precursor.
Their proposed randomized trial will test whether Plaque HD® reduces progression of atherosclerosis in the coronary and carotid arteries, for which systemic inflammation is an important precursor.
A report from the United States Centers for Disease Control and
Prevention found that 47.2 percent of American adults aged 30 years and older
have some form of periodontal disease, a pathological inflammatory condition of
the gums and tissues surrounding the teeth.
Periodontal disease increases with age affecting more than 70 percent of adults 65 years and older. Prior research has suggested that periodontal disease may be connected to variety of other diseases, including heart disease and stroke and other inflammatory diseases such as rheumatoid arthritis.
Inflammation throughout the body may be a crucial link between periodontal and other systemic diseases.
Periodontal disease increases with age affecting more than 70 percent of adults 65 years and older. Prior research has suggested that periodontal disease may be connected to variety of other diseases, including heart disease and stroke and other inflammatory diseases such as rheumatoid arthritis.
Inflammation throughout the body may be a crucial link between periodontal and other systemic diseases.
