New device expands on wearable tech
University of California - San Diego
Imagine being able to measure your
blood sugar levels, know if you've had too much to drink, and track your muscle
fatigue during a workout, all in one small device worn on your skin. 
The device can be worn on the upper arm while the wearer goes about
their day. Photos by Laboratory for Nanobioelectronics / UC San Diego
Engineers
at the University of California San Diego have developed a prototype of such a
wearable that can continuously monitor several health stats -- glucose,
alcohol, and lactate levels -- simultaneously in real-time.
The device is about the size of a stack of six quarters. It is applied to the skin through a Velcro-like patch of microscopic needles, or microneedles, that are each about one-fifth the width of a human hair.
Wearing the device is not painful -- the microneedles barely
penetrate the surface of the skin to sense biomolecules in interstitial fluid,
which is the fluid surrounding the cells beneath the skin. The device can be
worn on the upper arm and sends data wirelessly to a custom smartphone app.
EDITOR'S NOTE: I can attest to the comfort and convenience of these types of devices having worn one that measures my blood sugar level for a couple of years. It's a life-changer. Mine is about the same size as the device shown in the upper left, except I wear mine on the tricep. - Will Collette
Researchers at the UC San Diego Center for Wearable Sensors describe their device in a paper published May 9 in Nature Biomedical Engineering.
"This is like a complete lab on
the skin," said center director Joseph Wang, a professor of
nanoengineering at UC San Diego and co-corresponding author of the paper.
"It is capable of continuously measuring multiple biomarkers at the same
time, allowing users to monitor their health and wellness as they perform their
daily activities."
Most commercial health monitors,
such as continuous glucose monitors for patients with diabetes, only measure
one signal. The problem with that, the researchers said, is that it leaves out
information that could help people with diabetes, for example, manage their
disease more effectively. Monitoring alcohol levels is useful because drinking
alcohol can lower glucose levels. Knowing both levels can help people with
diabetes prevent their blood sugar from dropping too low after having a drink.
Combining information about lactate, which can be monitored during exercise as
a biomarker for muscle fatigue, is also useful because physical activity
influences the body's ability to regulate glucose.
"With our wearable, people can
see the interplay between their glucose spikes or dips with their diet,
exercise and drinking of alcoholic beverages. That could add to their quality
of life as well," said Farshad Tehrani, a nanoengineering Ph.D. student in
Wang's lab and one of the co-first authors of the study.
Microneedles merged with electronics
The wearable consists of a
microneedle patch connected to a case of electronics. Different enzymes on the
tips of the microneedles react with glucose, alcohol and lactate in
interstitial fluid. These reactions generate small electric currents, which are
analyzed by electronic sensors and communicated wirelessly to an app that the
researchers developed. The results are displayed in real time on a smartphone.
An advantage of using microneedles
is that they directly sample the interstitial fluid, and research has shown
that biochemical levels measured in that fluid correlate well with levels in
blood.
"We're starting at a really
good place with this technology in terms of clinical validity and
relevance," said Patrick Mercier, a professor of electrical and computer
engineering at UC San Diego and co-corresponding author of the paper.
"That lowers the barriers to clinical translation."
The microneedle patch, which is disposable,
can be detached from the electronic case for easy replacement. The electronic
case, which is reusable, houses the battery, electronic sensors, wireless
transmitter and other electronic components. The device can be recharged on any
wireless charging pad used for phones and smartwatches.
Integrating all these components
together into one small, wireless wearable was one of the team's biggest
challenges. It also required some clever design and engineering to combine the
reusable electronics, which must stay dry, with the microneedle patch, which
gets exposed to biological fluid.
"The beauty of this is that it
is a fully integrated system that someone can wear without being tethered to
benchtop equipment," said Mercier, who is also the co-director of the UC
San Diego Center for Wearable Sensors.
Testing
The wearable was tested on five
volunteers, who wore the device on their upper arm, while exercising, eating a
meal, and drinking a glass of wine. The device was used to continuously monitor
the volunteers' glucose levels simultaneously with either their alcohol or
lactate levels. The glucose, alcohol and lactate measurements taken by the
device closely matched the measurements taken respectively by a commercial
blood glucose monitor, Breathalyzer, and blood lactate measurements performed
in the lab.
Next steps
Farshad Tehrani and fellow co-first author Hazhir Teymourian, who is a former postdoctoral researcher in Wang's lab, co-founded a startup company called AquilX to further develop the technology for commercialization. Next steps include testing and improving upon how long the microneedle patch can last before being replaced. The company is also excited about the possibility of adding more sensors to the device to monitor medication levels in patients and other health signals.
