Study findings emphasize importance of taking a holistic approach to thinking about nutrients
Columbia University's Mailman School of Public Health
The
answer to a relatively concise question -- how does what we eat affect how we
age -- is unavoidably complex, according to a new study at the
Butler Columbia Aging Center at Columbia University Mailman School of Public
Health. 
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While most analyses had been concerned with the effects of a single nutrient on a single outcome, a conventional, unidimensional approach to understanding the effects of diet on health and aging no longer provides us with the full picture: healthy diet needs to be considered based on the balance of ensembles of nutrients, rather than by optimizing a series of nutrients one at a time.
Until now little was known about how normal variation in dietary
patterns in humans affects the aging process. The findings are published online
in the journal BMC Biology.
"Our ability to understand the problem has been complicated by the fact that both nutrition and the physiology of ageing are highly complex and multidimensional, involving a high number of functional interactions," said Alan Cohen, PhD, associate professor of environmental health sciences at Columbia Mailman School.
"This study therefore provides further support to the importance of looking beyond 'a single nutrient at a time' as the one size fits all response to the age-old question of how to live a long and healthy life."
Cohen
also points that the results are also concordant with numerous studies
highlighting the need for increased protein intake in older people, in
particular, to offset sarcopenia and decreased physical performance associated
with aging.
Using multidimensional modelling techniques to test the effects of nutrient intake on physiological dysregulation in older adults, the researchers identified key patterns of specific nutrients associated with minimal biological aging.
"Our approach presents a roadmap for future studies to explore the full
complexity of the nutrition-aging landscape," observed Cohen, who is also
affiliated with the Butler Columbia Aging Center.
The
researchers analyzed data from 1560 older men and women, aged 67-84 years
selected randomly between November 2003 and June 2005 from the Montreal, Laval,
or Sherbrooke areas in Quebec, Canada, who were re-examined annually for 3
years and followed over four years to assess on a large-scale how nutrient
intake associates with the aging process.
Aging and age-related loss of homeostasis (physiological dysregulation) were quantified via the integration of blood biomarkers. The effects of diet used the geometric framework for nutrition, applied to macronutrients and 19 micronutrients/nutrient subclasses.
Researchers fitted a series of eight models
exploring different nutritional predictors and adjusted for income, education
level, age, physical activity, number of comorbidities, sex, and current
smoking status.
Four
broad patterns were observed:
The
optimal level of nutrient intake was dependent on the aging metric used.
Elevated protein intake improved/depressed some ageing parameters, whereas
elevated carbohydrate levels improved/depressed others;
There
were cases where intermediate levels of nutrients performed well for many
outcomes (i.e. arguing against a simple more/less is better perspective);
There
is broad tolerance for nutrient intake patterns that don't deviate too much
from norms ('homeostatic plateaus').
Optimal
levels of one nutrient often depend on levels of another (e.g. vitamin E and
vitamin C). Simpler analytical approaches are insufficient to capture such
associations.
The
research team also developed an interactive tool to allow users to explore how
different combinations of micronutrients affect different aspects of aging.
The
results of this study are consistent with earlier experimental work in mice
showing that high-protein diets may accelerate aging earlier in life, but are
beneficial at older ages.
"These
results are not experimental and will need to be validated in other contexts.
Specific findings, such as the salience of the combination of vitamin E and
vitamin C, may well not replicate in other studies. But the qualitative finding
that there are no simple answers to optimal nutrition is likely to hold up: it
was evident in nearly all our analyses, from a wide variety of approaches, and
is consistent with evolutionary principles and much previous work," said
Cohen.
The
study was supported by the Australian Research Council (ARC DECRA:
DE180101520), the Canadian Institutes of Health Research (CIHR) grants 153011
and 62842; as well as grants from Fonds de recherche du Que?bec(FRQ) grant #2020-VICO-279753,
Quebec Network for Research on Aging.
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Source:
Materials provided by Columbia
University's Mailman School of Public Health. Note:
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