Third major study to show their benefits
Mass General Brigham
The COcoa Supplement and Multivitamin Outcomes Study (COSMOS) is a large-scale, nationwide, randomized trial rigorously testing cocoa extract and multivitamin supplements directed by researchers at Mass General Brigham.
Two previously published studies of cognition in COSMOS suggested a positive effect for a daily multivitamin. COSMO researchers now report the results of a third study of cognition in COSMOS, which focused on participants who underwent in-person assessments, together with the results of a combined analysis from the three separate studies.
The results from this latest report confirm consistent and
statistically significant benefits of a daily multivitamin versus placebo for
both memory and global cognition. Results are published today in The American
Journal of Clinical Nutrition.
"Cognitive decline is among the top health concerns for most older adults, and a daily supplement of multivitamins has the potential as an appealing and accessible approach to slow cognitive aging," said first author Chirag Vyas, MBBS, MPH, instructor in investigation at the Department of Psychiatry at Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system.
In the in-clinic study
the researchers administered detailed, in-person cognitive assessments among
573 participants in the subset of COSMOS known as COSMOS-Clinic.
Within COSMOS, two
previous studies had tested multivitamin supplementation on cognition using
telephone-based cognitive assessments (COSMOS-MIND) and online web-based
cognitive assessments (COSMOS-Web). In their prespecified analyses of data from
COSMOS-Clinic, investigators observed a modest benefit for the multivitamin,
compared to placebo, on global cognition over two years.
There was a
statistically significant benefit of multivitamin supplementation for change in
episodic memory, but not in executive function/attention.
The team also conducted
a meta-analysis based on the three separate studies, with non-overlapping
COSMOS participants (ranging 2-3 years in treatment duration), which showed
strong evidence of benefits for both global cognition and episodic memory.
The authors estimate
that the daily multivitamin slowed global cognitive aging by the equivalent of
two years compared to placebo.
Vyas said, "The meta-analysis of three separate cognition studies provides strong and consistent evidence that taking a daily multivitamin, containing more than 20 essential micronutrients, helps prevent memory loss and slow down cognitive aging."
Olivia Okereke, MD SM, senior author of the report and director of
Geriatric Psychiatry at MGH, added "These findings will garner attention
among many older adults who are, understandably, very interested in ways to
preserve brain health, as they provide evidence for the role of a daily
multivitamin in supporting better cognitive aging."
The overall COSMOS trial
is led by JoAnn Manson, MD, DrPH, and Howard Sesso, ScD, MPH, both of Brigham
and Women's Hospital (BWH), also a founding member of Mass General Brigham.
Manson, co-author of the
report and Chief of the Division of Preventive Medicine at BWH, commented:
"The finding that a daily multivitamin improved memory and slowed
cognitive aging in three separate placebo-controlled studies in COSMOS is
exciting and further supports the promise of multivitamins as a safe,
accessible and affordable approach to protecting cognitive health in older
adults."
The COSMOS consortium of
cognitive studies represents a collaboration between MGH, BWH, Columbia
University, and Wake Forest University, using both traditional and innovative
approaches to assessing cognitive outcomes.
These approaches allow
large numbers of participants (>5,000 in total) to be included in cognitive
studies in a high-quality and cost-efficient manner.
COSMOS participants are
aged 60 and older and reside throughout the U.S.
Sesso, also a co-author and the associate director of the BWH Division of Preventive Medicine, added: "With these three studies using different approaches for assessing cognition in COSMOS, each providing support for a daily multivitamin, it is now critical to understand the mechanisms by which a daily multivitamin may protect against memory loss and cognitive decline with a focus on nutritional status and other aging-related factors. For example, the modifying role of baseline nutritional status on protecting against cognitive decline has been shown for the COSMOS cocoa extract intervention. A typical multivitamin such as that tested in COSMOS contains many essential vitamins and minerals that could explain its potential benefits."
