Daily Fiber Supplement Improves Senior Cognition in Just 12 Weeks

Brain Boost

By KING’S COLLEGE LONDON 

The study, published recently in Nature Communications by researchers from the School of Life Course & Population Sciences at King’s College London showed that this simple and cheap addition to diet can improve performance in memory tests associated with early signs of Alzheimer’s disease.

However, the prebiotic supplements inulin and FOS were found to have no effect on muscle strength over this period.

As populations age globally, the prevalence of age-related conditions such as cognitive decline and muscle loss is on the rise. 

Researchers at TwinsUK, the UK’s largest adult twin registry based at King’s College London, sought to understand how targeting the microbiota, the diverse community of microorganisms residing in our intestines, using two cheap, commercially available plant fiber supplements inulin and FOS, could impact both muscle health and brain function.

Researchers assigned 36 twin pairs – 72 individuals – over 60 years old to receive either a placebo or the supplement every day for 12 weeks. Neither the analysis team, nor the participants knew which they received until the analysis was complete (double-blind). Alongside this, all study participants did resistance exercises and ate a protein supplement which was aimed at improving muscle function.

Researchers monitored participants remotely via video, online questionnaires, and cognitive tests. They found the fiber supplement led to significant changes in the participants’ gut microbiome composition, particularly an increase in the numbers of beneficial bacteria such as Bifidobacterium.

While there was no significant difference in muscle strength between the groups, the group receiving the fiber supplement performed better in tests assessing brain function, including the Paired Associates Learning test which is an early marker for Alzheimer’s disease, together with tests of reaction time and processing speed. 

These measures are important for daily living – for example, reacting to traffic or stopping a simple trip-up turning into a fall.

Another novel aspect of the study was its remote design which demonstrated the feasibility of conducting trials in older adults without the need for extensive travel or hospital visits, which could be delivered in many settings globally. 

Challenges such as digital literacy and access to the necessary technology were acknowledged and will be addressed in future larger-scale projects with the aim of enhancing the quality of life for aging populations worldwide.

Reference: “Effect of gut microbiome modulation on muscle function and cognition: the PROMOTe randomised controlled trial” by Mary Ni Lochlainn, Ruth C. E. Bowyer, Janne Marie Moll, María Paz García, Samuel Wadge, Andrei-Florin Baleanu, Ayrun Nessa, Alyce Sheedy, Gulsah Akdag, Deborah Hart, Giulia Raffaele, Paul T. Seed, Caroline Murphy, Stephen D. R. Harridge, Ailsa A. Welch, Carolyn Greig, Kevin Whelan and Claire J. Steves, 29 February 2024, Nature Communications.
DOI: 10.1038/s41467-024-46116-y