This is where millions of men cover their crotches
By
Michael Haederle
In a new paper published
in the journal Toxicological Sciences, a team led by
Xiaozhong “John” Yu, MD, PhD, MPH, a professor in the UNM College of Nursing,
reported finding 12 types of microplastics in 47 canine and 23 human testes.
“Our
study revealed the presence of microplastics in all human and canine testes,”
Yu said. The team was also able to quantify the amount of microplastics in the
tissue samples using a novel analytical method that revealed correlations
between certain types of plastic and reduced sperm count in the canine samples.
Yu, who studies the impact of various environmental factors on the human reproductive system, said heavy metals, pesticides and endocrine-disrupting chemicals have all been implicated in a global decline in sperm count and quality in recent years.
A conversation with his colleague Matthew Campen, PhD,
a professor in the UNM College of Pharmacy who has documented the presence of
microplastics in human placentas, led him to wonder whether something else
might be at work.
“He
said, ‘Have you considered why there is this decline (in reproductive
potential) more recently? There must be something new,’” Yu said. That led Yu
to design a study using the same experimental method Campen’s lab had used in
the placenta research.
His
team obtained anonymized human tissue from the New Mexico Office of the Medical
Investigator, which collects tissue during autopsies and stores it for seven
years before disposing of it. The canine tissue came from City of Albuquerque
animal shelters and private veterinary clinics that perform spay-neutering
operations.
The
team chemically treated the samples to dissolve the fat and proteins and spun
each sample in an ultracentrifuge, leaving a nugget of plastic at the bottom of
a tube. Then, heated the plastic pellet in a metal cup to 600 degrees Celsius.
They used a mass spectrometer to analyze gas emissions as different types of
plastic burned at specific temperatures.
In
dogs, the average concentration of microplastics in testicular tissue was
122.63 micrograms per gram of tissue (a microgram is a millionth of a gram). In
human tissue the average concentration was 329.44 micrograms per gram – nearly
three times higher than in dogs and significantly higher than the average
concentration Campen found in placental tissue.
“At
the beginning, I doubted whether microplastics could penetrate the reproductive
system,” Yu said. “When I first received the results for dogs I was surprised.
I was even more surprised when I received the results for humans.”
The
researchers found the most prevalent polymer in both human and canine tissue
was polyethylene (PE), which is used to make plastic bags and bottles. In dogs
that was followed by PVC, which is used in industrial, municipal and household
plumbing and in many other applications.
The
team was able to count the sperm in the canine samples (but not in the human
ones, which had been chemically preserved) and found that higher levels of PVC
in the tissue correlated with a lower sperm count, Yu said. There was no
correlation with tissue concentration of PE, however.
“The
plastic makes a difference – what type of plastic might be correlated with
potential function,” he said. “PVC can release a lot of chemicals that
interfere with spermatogenesis and it contains chemicals that cause endocrine
disruption.”
The
study compared human and canine tissue for a couple of reasons, one being that
dogs live alongside people and share their environment. They also share some
biological characteristics.
“Compared
to rats and other animals, dogs are closer to humans,” he said. “Physically,
their spermatogenesis is closer to humans and the concentration has more
similarity to humans.” Canine sperm counts also seem to be dropping, he added.
“We believe dogs and humans share common environmental factors that contribute
to their decline.”
Microplastics result when plastic is exposed to ultraviolet radiation in sunlight and degrades in landfills. It can be blown about by the wind or carried into nearby waterways, and some bits are so small they are measured in nanometers (a billionth of a meter). They’re now ubiquitous in the environment – even as global use of plastics continues to grow.
Yu noted that the average age of the
men in the OMI autopsy samples was 35, meaning their plastics exposure began
decades ago, when there was less plastic in circulation. “The impact on the
younger generation might be more concerning,” now that there is more plastic
than ever in the environment, he said.
The
findings point the way for additional research to understand how microplastics
might affect sperm production in the testes, he said. “We have a lot of
unknowns. We need to really look at what the potential long-term effect. Are
microplastics one of the factors contributing to this decline?”
In
disseminating his findings, Yu doesn’t want anyone to panic. “We don’t want to
scare people,” he said. “We want to scientifically provide the data and make
people aware there are a lot of microplastics. We can make our own choices to
better avoid exposures, change our lifestyle and change our behavior.”
